Vitamin K‐dependent carboxylase Possible role for thioredoxin in the reduction of vitamin K metabolites in liver

FEBS Letters

Vermeer, Cees¹  van Haarlem, L.Johan M.¹  Soute, Berry A.M.¹ 

[1] Department of Biochemistry, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands

关键词: Vitamin K;    γ-Carboxyglutamic acid;    Thioredoxin;    Carboxylase;    Warfarin;   

DOI  :  10.1016/0014-5793(87)80401-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the liver vitamin K epoxide, which is produced during the posttranslational carboxylation of proteinbound glutamic acid residues, is recycled by the action of one or more dithiol-dependent reductases. In vitro synthetic dithiols may serve as a cofactor for these enzymes, but the physiological reluctant has not yet been found. In this paper we report that in vitro the commercially available thioredoxin/thioredoxin reductase from E. coli can replace the synthetic dithiols during the various reactions of the vitamin K cycle. Based on the assumption that in vivo thioredoxin also plays a role in the regeneration of vitamin K hydroquinone from the epoxide, an extension of the generally accepted vitamin K cycle is proposed.

【 授权许可】

Unknown