FEBS Letters | |
Vitamin K‐dependent carboxylase Possible role for thioredoxin in the reduction of vitamin K metabolites in liver | |
Vermeer, Cees1  van Haarlem, L.Johan M.1  Soute, Berry A.M.1  | |
[1] Department of Biochemistry, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands | |
关键词: Vitamin K; γ-Carboxyglutamic acid; Thioredoxin; Carboxylase; Warfarin; | |
DOI : 10.1016/0014-5793(87)80401-5 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In the liver vitamin K epoxide, which is produced during the posttranslational carboxylation of proteinbound glutamic acid residues, is recycled by the action of one or more dithiol-dependent reductases. In vitro synthetic dithiols may serve as a cofactor for these enzymes, but the physiological reluctant has not yet been found. In this paper we report that in vitro the commercially available thioredoxin/thioredoxin reductase from E. coli can replace the synthetic dithiols during the various reactions of the vitamin K cycle. Based on the assumption that in vivo thioredoxin also plays a role in the regeneration of vitamin K hydroquinone from the epoxide, an extension of the generally accepted vitamin K cycle is proposed.
【 授权许可】
Unknown
【 预 览 】
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RO201912020289789ZK.pdf | 304KB | download |