The binding of Gla‐containing proteins to phospholipids

FEBS Letters

Vermeer, Cees¹ 

[1] Department of Biochemistry, University of Limburg, PO Box 616, 6200 MD Maastricht, The Netherlands

关键词: Vitamin K;    γ-Carboxyglutamic acid;    Prothrombin;    Osteocalcin;    Blood coagulation;    Carboxylase;   

DOI  :  10.1016/0014-5793(84)81040-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is demonstrated here that osteocalcin, the Gla-containing protein from bone, is unable to interfere with the binding of the blood coagulation factors to phospholipid vesicles. Therefore, it seems that besides the Gla residues other structural features of the coagulation factors are required for their effective binding to phospholipid surfaces.

【 授权许可】

Unknown