The 3′‐orf protein of human immunodeficiency virus 2 shows sequence homology with the bel3 gene of the human spumaretrovirus

FEBS Letters

Maurer, Bernd¹  Flügel, Rolf M.¹ 

[1] German Cancer Research Center, Institute of Virus Research, PO Box 101949, 6900 Heidelberg, FRG

关键词: 3′-orf protein;    Human foamy virus;    Human immunodeficiency virus;    tat gene;    Sequence homology;    AIDS;    acquired immunodeficiency syndrome;    HIV;    human immunodeficiency virus;    HSRV;    human spumaretrovirus;    orf;    open reading frame;    bel;    between env and LTR;    tat;    trans-acting transcription activator;   

DOI  :  10.1016/0014-5793(87)80387-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The primary amino acid sequence within a domain of 89 residues of the central part of the 3′-orf protein (p27 3′-orf) of human immunodeficiency virus (HIV-2) shares homology with the middle and carboxy-terminal portion of the bel3 gene product of human spumaretrovirus (HSRV). In addition, a limited region of the tat protein of HIV-2 but not HIV-1 shows a 28% degree of homology to the deduced protein sequence of the bel1 gene product of HSRV. Comparison between the viral sequences suggests that the 3′-orf and bel1 gene product of HSRV could serve similar functions to those in HIV-2.

【 授权许可】

Unknown