Recombinant human B cell stimulatory factor 2 (BSF‐2/IFN‐β2) regulates β‐fibrinogen and albumin mRNA levels in Fao‐9 cells

FEBS Letters

Andus, Tilo²  Ganter, Ursula³  Bauer, Joachim³  Geiger, Thomas²  Kishimoto, Tadamitsu¹  Heinrich, Peter C.²  Hirano, Toshio¹  Northoff, Hinnak⁴ 

[1] Institute for Molecular and Cellular Biology, Division of Immunology, Osaka University, 1-3, Yamada-oka, Suita, Osaka 565, Japan;Biochemisches Institut, Universität Freiburg, Hermann-Herder-Str. 7, D-7800 Freibrug, FRG;Medizinische Universitätsklinik, Hugstetter Str. 55, D-7800 Freiburg, FRG;Hinnak Northoff, Blutspendezentrale des DRK, Oberer Eselsberg, D-7900 Ulm Germany

关键词: Acute-phase protein;    Albumin;    BSF-2;    β-Fibrinogen;    Hepatocyte-stimulating factor;    Interferon-β2;    BSF-2;    B-cell differentiation factor;    FCS;    fetal calf serum;    HSF;    hepatocyte-stimulating factor;    rhIFN-β2;    recombinant human interferon-β2;   

DOI  :  10.1016/0014-5793(87)80344-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Conditioned medium from human monocytes contains a partially characterized hepatocyte-stimulating factor that simultaneously elevates the mRNA levels of the acute-phase protein β-fibrinogen and decreases albumin mRNA in rat hepatoma cells. We demonstrate that recombinant human B-cell stimulatory factor 2, which is identical to interferon-β2/26 kDa protein and interleukin-HP1, exhibits the same activity as hepatocyte-stimulating factor. Furthermore, a specific antibody against B-cell stimulatory factor 2 was able to inhibit hepatocyte-stimulating factor in conditioned medium from human monocytes. Our data show that hepatocyte-stimulating factor and B-cell stimulatory factor 2 are functionally and immunologically related proteins.

【 授权许可】

Unknown