Dexamethasone regulation of the expression of cytokine mRNAs induced by interleukin‐1 in the astrocytoma cell line U373MG

FEBS Letters

Aihara, Koutoku¹  Nakai, Satoru¹  Nishida, Tsutomu¹  Kawakami, Takuma¹  Hirai, Yoshikatsu¹  Nishino, Naoki¹ 

[1] Cellular Technology Institute, Otsuka Pharmaceutical Co., 463-10 Kagasuno, Kawauchi-cho, Tokushima 771-01, Japan

关键词: Interleukin-1;    B-cell stimulatory factor-2;    Interleukin-6;    Granulocyte-macrophage colony-stimulating factor;    Dexamethasone;    Astrocytoma;    IL-1;    interleukin-1;    BSF-2;    B-cell stimulatory factor-2;    IL-6;    interleukin-6;    GM-CSF;    granulocytemacrophage colony-stimulating factor;    rIL-1;    recombinant IL-1;    LPS;    lipopolysaccharide;   

DOI  :  10.1016/0014-5793(89)81210-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

BSF-2/IL-6, GM-CSF and IL-1β mRNAs were induced by recombinant IL-1 in human astrocytoma cell line U373MG. The induction of BSF-2/IL-6 and IL-1β mRNAs did not require de novo protein synthesis while that of GM-CSF mRNA required a newly synthesized protein. Dexamethasone inhibited the induction of these cytokine mRNAs by IL-1. This process seems to require continued protein synthesis. These results suggest that the production of these cytokines are positively and negatively controlled by IL-1 and glucocorticoids, respectively, in astrocytes.

【 授权许可】

Unknown