Interleukin‐2 binding to activated human T lymphocytes triggers generation of cyclic AMP but not of inositol phosphates

FEBS Letters

Hoffbrand, A.Victor¹  Mire-Sluis, Anthony R.¹  Wickremasinghe, R.Gitendra¹ 

[1] Department of Haematology, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, England

关键词: Lymphokine;    Second messenger;    Inositol lipid;    Protein phosphorylation;    Growth factor;   

DOI  :  10.1016/0014-5793(87)80874-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Human T lymphocytes stimulated with phytohaemagglutinin undergo a single round of cell division. Further proliferation is dependent on the lymphokine interleukin-2 (IL2) [(1987) Immunology 60, 7–12]. We show here that binding of IL2 to its receptors on the lymphocyte surface triggers the generation of cyclic AMP. In contrast, generation of inositol phosphates from the breakdown of inositol lipids was not detected. We suggest that cyclic AMP may play a role in the transduction of the IL2 proliferative signal in T lymphocytes.

【 授权许可】

Unknown