Translation of mRNA for human lymphotoxin in microinjected Xenopus oocytes

FEBS Letters

Wallach, David¹  Budilovsky, Sylvia¹  Hahn, Talia¹ 

[1] Department of Virology, The Weizmann Institute of Science, Rehovot, Israel

关键词: Lymphotoxin;    mRNA translation;    Interferon-γ;    Lymphokine;    Lymphocyte stimulation;    Oocyte;    CHI;    cycloheximide;    IFN;    interferon;    LT;    lymphotoxin;   

DOI  :  10.1016/0014-5793(84)80612-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Synthesis and secretion of biologically active human lymphotoxin (LT) can be detected in Xenopus laevis oocytes following their inoculation with poly(A⁺) RNA from human stimulated peripheral blood lymphocytes, but not in oocytes inoculated with RNA from unstimulated lymphocytes or from fibroblastoid cells. In size-fractionating mRNA of stimulated lymphocytes most LT activity is found to be coded for by RNA with an approximate sedimentation value of 19 S.

【 授权许可】

Unknown