Role of Mg2+ in the ribozyme system

FEBS Letters

Imamura, Akira¹  Toh, Hiroyuki²  Kanda, Katsuya¹ 

[1] Department of Chemistry, Faculty of Science, Hiroshima University, Hiroshima 730, Japan;Department of Biology, Faculty of Science, Kyushu University, Fukuoka 812, Japan

关键词: Ribozyme;    Mg2+;    Ab initio molecular orbital calculation;   

DOI  :  10.1016/0014-5793(87)80235-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recently, several kinds of catalytic activities have been identified from L-19 IVS RNA or ‘ribozyme’. In the catalytic process of ribozyme, Mg²⁺ is required. We investigated the role of Mg²⁺ by molecular orbital calculation. Based on the results of the calculation, a model for the self-splicing reaction was constructed.

【 授权许可】

Unknown