α1‐Adrenergic stimulation causes Mg2+ release from perfused rat liver

FEBS Letters

Schöttli, Gertrud²  Fritzsch, Günter¹  Becker, Johannes²  Jakob, Andrea² 

[1] Max Planck Institute of Biophysics, Heinr. Hoffmann-Str. 7, D-6000 Frankfurt/Main 71, FRG;Department of Biochemistry, Vesalianum, University of Basel, Vesalgasse 1, CH-4051 Basel, Switzerland

关键词: Mg2+;    Perfusion;    Adrenergic agonist;    α1-;    (Rat liver);   

DOI  :  10.1016/0014-5793(89)80267-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The possibility that Mg²⁺ mobilization is stimulated in perfused liver by α₁-adrenergic agonists was studied by measuring Mg²⁺ release in response to 0.5 and 20μM phenylephrine. During preperfusion exogenous Mg²⁺ was added to the medium to give 1.2 mM. 5 min before starting the addition of phenylephrine the infusion of exogenous Mg²⁺ was stopped. Mg²⁺ in the perfusate leaving the liver was measured by atomic absorption spectroscopy. Analysis of the Mg²⁺ decay curves with two exponential models indicated that phenylephrine caused dose-dependent Mg²⁺ release from perfused rat livers.

【 授权许可】

Unknown