Effects of magnesium and sodium ions on the outer membrane permeability of cephalosporins in Escherichia coli

FEBS Letters

Tomiyama, Noribumi¹  Yamaguchi, Akihito¹  Yanai, Misa¹  Sawai, Tetsuo¹ 

[1] Division of Microbial Chemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Chiba 260, Japan

关键词: Mg2+ effect Na+ effect Membrane permeability Cephalosporin (E. coli);   

DOI  :  10.1016/0014-5793(86)81528-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Both Mg²⁺ and Na⁺ stimulated the outer membrane permeation of negatively charged cephalosporins in Escherichia coli without any significant alteration of the permeation of a zwitterionic cephalosporin. Such stimulation was not observed in an E. coli mutant lacking porins. The stimulation was caused by the direct interaction between the cations and the porin pores, which resulted in a decrease in cation selectivity of both the Omp F and Omp C porin pores.

【 授权许可】

Unknown