Brain 14‐3‐3 protein is an activator protein that activates tryptophan 5‐monooxygenase and tyrosine 3‐monooxygenase in the presence of Ca2+,calmodulin‐dependent protein kinase II

FEBS Letters

Ichimura, Tohru¹  Okuyama, Tsueno¹  Yamauchi, Takashi²  Fujisawa, Hitoshi²  Isobe, Toshiaki¹ 

[1] Department of Chemistry, Faculty of Science, Tokyo Metropolitan University, Setagaya, Tokyo 158 Japan;Department of Biochemistry, Asahikawa Medical College, Asahikawa 078-11, Japan

关键词: 14-3-3 protein;    Activator protein;    Tryptophan 5-monooxygenase;    Tyrosine 3-monooxygenase;    Ca2+/calmodulin-dependent protein kinase;    (Brain);   

DOI  :  10.1016/0014-5793(87)81194-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have found that the 14-3-3 protein, an acidic neuronal protein, is substantially identical to the ‘activator’ protein [(1981) J. Biol. Chem. 256, 5404–5409] that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca²⁺,calmodulin dependent protein kinase II. This finding is based on the remarkable similarity of both these proteins in physicochemical, biochemical and immunochemical properties, as well as on detection for the 14-3-3 protein of an activator activity towards tryptophan 5-monooxygenase. The result suggests that the 14-3-3 protein plays a role in the regulation of serotonin and noradrenaline biosynthesis in brain.

【 授权许可】

Unknown