ATP‐sensitive K+ channels in human isolated pancreatic B‐cells

FEBS Letters

Kelly, Ronan P.¹  Kakei, Masafumi¹  Sutton, Robert²  Ashcroft, Frances M.¹ 

[1] University Laboratory of Physiology, Parks Rd, Oxford OX1 3PT, England;Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DU, England

关键词: ATP sensitivity;    K+ channel;    Patch clamp;    Insulin secretion;    (Pancreatic B-cell);   

DOI  :  10.1016/0014-5793(87)80103-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucose-stimulated insulin release from rodent pancreatic B-cells is thought to be initiated by the closing of ATP-sensitive K⁺ channels in the plasma membrane as a consequence of glucose metabolism. We have identified an ATP-sensitive K⁺ channel in membrane patches excised from human B-cells which is similar to that found in rodent B-cells in conductance, kinetics, ATP sensitivity and its inhibition by sulphonylureas. In man, the ATP-sensitive K⁺ channel may also have a central role in glucose-stimulated insulin secretion and may be (linked to) the receptor for the hypoglycemic sulphonylureas.

【 授权许可】

Unknown