Alanine and lactate as gluconeogenic substrates during late gestation

FEBS Letters

Chamorro, M.¹  Cuezva, J.M.¹  Valcarce, C.¹  Franco, A.¹  Mayor, F.¹ 

[1] Departamento de Bioquímica y Biologin Molecular, Centro de Biologia Molecular, UAM-CSIC, Universidad Aùtônoma de Madrid, Canto Blanco, 28049 Madrid, Spain

关键词: Gluconeogenesis;    Gestation;    Hepatocyte;    Lactate;    Alanine;   

DOI  :  10.1016/0014-5793(86)80088-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rates of alanine incorporation into glucose by isolated liver cells of fed rats are 5-fold higher than those observed when lactate was used as substrate. The rates of gluconeogenesis from alanine and lactate in isolated liver cells of fed pregnant rats increase 50 and 200–400%, respectively, over virgins during the last 3 days of gestation. The results support the existence of an increase in the alanine-glucose cycle in the late pregnancy as an important homeostatic pathway in the supply of glucose to the growing fetus.

【 授权许可】

Unknown