Angiotensin II inhibits hepatic cAMP accumulation induced by glucagon and epinephrine and their metabolic effects

FEBS Letters

Exton, John H.¹  Blackmore, Peter F.¹  Morgan, Noel G.¹ 

[1] Laboratories for the Studies of Metabolic Disorders, Howard Hughes Medical Institute and Department of Physiology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA

关键词: Hepatocyte;    Glucagon;    Angiotensin II;    cAMP;    Phosphorylase;    Gluconeogenesis;   

DOI  :  10.1016/0014-5793(83)80122-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Incubation of isolated hepatocytes containing normal Ca²⁺ levels with angiotensin II, vasopressin or A23187 caused significant inhibition of the cAMP response to glucagon. Angiotensin II also inhibited cAMP accumulation induced by either glucagon or epinephrine in Ca²⁺-depleted hepatocytes. When sub-maximal doses of hormone were employed such that cell cAMP was elevated only 3–4-fold (∼2 pmol cAMP/mg wet wt cells) inhibition by angiotensin II was correlated with a decrease in phosphorylase activation. The data demonstrate that inhibition of hepatic cAMP accumulation results in reduced metabolic responses to glucagon and epinephrine and do not support the contention that the hepatic actions of glucagon are independent of cAMP.

【 授权许可】

Unknown