Glucagon‐like peptides activate hepatic gluconeogenesis

FEBS Letters

Andrews, P.C.³  Plisetskaya, Erika M.¹  Mommsen, Thomas P.² 

[1] Department of Zoology NJ-15, University of Washington, Seattle, WA 98195, USA;Department of Zoology, University of British Columbia, Vancouver V6T 2A9, Canada;Department of Biochemistry, Purdue University, West Lafayette, IN 47907 USA

关键词: Hepatocyte;    Teleost;    Gluconeogenesis;    Lactate oxidation;    cyclic AMP;    Glucagon;    Glucagon-like peptide;   

DOI  :  10.1016/0014-5793(87)81222-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Piscine (anglerfish, catfish, coho salmon) glucagon-like peptides (GLPs), applied at 3.5 nM, stimulate (1.1–1.9-fold) flux through gluconeogenesis above control levels in isolated trout and salmon hepatocytes. Human GLP-1 and GLP-2 also activate gluconeogenesis, but to a lesser degree than their piscine counterparts. Minor increases of substrate oxidation are noticed at times of peak gluconeogenic activation through GLPs. These hormones, which are derived from the same precursor peptide as glucagon are more potent activators of gluconeogenesis than glucagon when applied at equimolar concentrations, and do not appear to employ cAMP or cGMP as the intracellular messenger in hepatic tissue.

【 授权许可】

Unknown