Increased mitochondrial creatine kinase in chronically stimulated fast‐twitch rabbit muscle

FEBS Letters

Schmitt, Thomas¹  Pette, Dirk¹ 

[1] Faculty of Biology, University of Konstanz, D-7750 Konstanz, FRG

关键词: Creatine kinase isozyme;    Mitochondria;    Cytosolic;    Skeletal muscle;    Chronic nerve stimulation;   

DOI  :  10.1016/0014-5793(85)80399-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Fractional extraction and isozyme electrophoresis revealed the presence of small amounts (2.5 % of total cellular activity) of mitochondrial creatine kinase (CK) in rabbit fast-twitch muscle. Chronic nerve stimulation resulted in a decrease of extramitochondrial MM-CK to 60% of its normal value but induced an approx. 4-fold increase in mitochondrial CK. This increase occurred in parallel with the rise in enzyme activities of terminal substrate oxidation.

【 授权许可】

Unknown