GTP enhances inositol trisphosphate‐stimulated Ca2+ release from rat liver microsomes

FEBS Letters

Dawson, A.P.¹ 

[1] School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, England

关键词: Calcium;    Inositol 1;    4;    5-trisphosphale;    GTP;    Microsome;    Polyethylene glycol;    Polyphosphoinositide;   

DOI  :  10.1016/0014-5793(85)80759-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Low concentrations of GTP (10–50 μM) greatly enhance the inositol 1,4,5-trisphosphate stimulated Ca²⁺ release from rat liver microsomal vesicles. The effect of GTP depends on the presence of low concentrations of polyethylene glycol in the incubation medium. Guanylyl imidodiphosphate is ineffective at mimicking the GTP effect and inhibits the action of GTP added subsequently.

【 授权许可】

Unknown