2‐5A‐dependent endoribonuclease activity and effects of A2'p5'A2'p5'A (2‐5A core) in mouse pancreatic islets

FEBS Letters

Taylor, Keith W.¹  Rhodes, Christopher J.¹ 

[1] Department of Biochemistry, The London Hospital Medical College, Turner Street, Whitechapel, London E1 2AD, England

关键词: Insulin biosynthesis;    Oligoadenylate;    Interferon;    Islets of Langerhans;    Endoribonuclease;   

DOI  :  10.1016/0014-5793(85)80233-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glucose-stimulated (pro)insulin biosynthesis is markedly inhibited is mouse pancreatic islets incubated with micromolar concentrations of 2-5A ‘core’, (A2'p5'A2'p5'A). Total protein synthesis was also reduced, but to a lesser extent, while insulin release and total insulin content of the islets was untouched by 2-5A ‘core’. Evidence is given for the presence of a 2-5A-dependent endoribonuclease which mediates these effects.

【 授权许可】

Unknown