Poly(ADP‐ribose) polymerase activity is inhibited by 2',5'‐oligoadenylates in mouse L‐cells

FEBS Letters

Malanga, Maria¹  Romeo, Giovanna⁵  Coccia, Eliana M.⁵  Suzuki, Hisanori²  Buonamassa, Daniela Tornese³  Farina, Benedetta¹  Affabris, Elisabetta⁴ 

[1] Dipartimento di Chimica Organica e Biologica, Università di Napoli, 80134 Napoli, Italy;Istituto di Chimica Biologica, Università di Verona, 37134 Verona, Italy;Centra Ricerche Sclavo, 53100 Siena, Italy;Istituto di Microbiologia, Università di Messina, Messina, Italy;Laboratorio di Virologia, Istituto Superiore di Sanità, 00161 Roma, Italy

关键词: Oligoadenylate;    2';    5'-;    Poly(ADP-ribose)polymerase;   

DOI  :  10.1016/0014-5793(89)81641-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Down regulation of poly(ADP-ribose)polymerase (ADPRP) activity was observed in mouse LW-cells after treatment with 2'-5'oligoadenylates or with fibroblast interferon and poly(rI).poly(rC). The poly(rI).poly(rC)-induced inhibition of the enzymatic activity correlates with the observed increase of endogenous 2',5'-oligoadenylate cores which were reported to be potent inhibitors of ADPRP in vitro.

【 授权许可】

Unknown