期刊论文详细信息
FEBS Letters | |
Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells) | |
Berridge, Michael J.3  Putney, James W.1  Irvine, Robin F.2  McKinney, Jerry S.1  Burgess, Gillian M.1  Hoyle, Peter C.1  | |
[1] Department of Pharmacology, Medical College of Virginia, Richmond, VA 23298-0001, USA;Department of Biochemistry, AFRC Institute of Animal Physiology, Babraham, Cambridge CB2 4A T UK;AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB23EJ, England | |
关键词: HL-60 cell; f-Met-Leu-Phe; Calcium; Inositol 1; 4; 5-trisphosphate; Intracellular messenger; DMSO; dimethyl sulphoxide; FMLP; formylmethionylleucylphenylalanine; PI(4; 5)P2; phosphatidylinositol 4; 5-bisphosphate; IP3; inositol trisphosphate; (1; 4; 5)IP3; inositol 1; 4; 5-trisphosphate; ER; endoplasmic reticulum; (4; 5)IP2; inositol 4; 5-bisphosphate; | |
DOI : 10.1016/0014-5793(84)80939-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Pemeabilised, dimethyl sulphoxide-differentiated HL-60 human myelomonocytic leukemia cells accumulate 45Ca in an ATP-dependent manner. The 45Ca is taken up by a pool thought to be a component of the endoplasmic reticulum. Inositol trisphosphate induced a rapid release of Ca from this pool, suggesting that this molecule which is formed in these cells in response to f-Met-Leu-Phe may play a role in agonist-induced Ca metabolism.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020285967ZK.pdf | 403KB | download |