Inositol 1,4,5‐trisphosphate may be a signal for f‐Met‐Leu‐Phe‐induced intracellular Ca mobilisation in human leucocytes (HL‐60 cells)

FEBS Letters

Berridge, Michael J.³  Putney, James W.¹  Irvine, Robin F.²  McKinney, Jerry S.¹  Burgess, Gillian M.¹  Hoyle, Peter C.¹ 

[1] Department of Pharmacology, Medical College of Virginia, Richmond, VA 23298-0001, USA;Department of Biochemistry, AFRC Institute of Animal Physiology, Babraham, Cambridge CB2 4A T UK;AFRC Unit of Insect Neurophysiology and Pharmacology, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB23EJ, England

关键词: HL-60 cell;    f-Met-Leu-Phe;    Calcium;    Inositol 1;    4;    5-trisphosphate;    Intracellular messenger;    DMSO;    dimethyl sulphoxide;    FMLP;    formylmethionylleucylphenylalanine;    PI(4;    5)P2;    phosphatidylinositol 4;    5-bisphosphate;    IP3;    inositol trisphosphate;    (1;    4;    5)IP3;    inositol 1;    4;    5-trisphosphate;    ER;    endoplasmic reticulum;    (4;    5)IP2;    inositol 4;    5-bisphosphate;   

DOI  :  10.1016/0014-5793(84)80939-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Pemeabilised, dimethyl sulphoxide-differentiated HL-60 human myelomonocytic leukemia cells accumulate ⁴⁵Ca in an ATP-dependent manner. The ⁴⁵Ca is taken up by a pool thought to be a component of the endoplasmic reticulum. Inositol trisphosphate induced a rapid release of Ca from this pool, suggesting that this molecule which is formed in these cells in response to f-Met-Leu-Phe may play a role in agonist-induced Ca metabolism.

【 授权许可】

Unknown