Degradation of soluble collagen by ozone or hydroxyl radicals

FEBS Letters

Amoruso, Marie A.¹  Berg, Richard A.²  Curran, Samantha F.²  Goldstein, Bernard D.¹ 

[1] Department of Environmental and Community Medicine, UMDNJ-Rutgers Medical School, Piscataway, NJ 08854, USA;Department of Biochemistry, UMDNJ-Rutgers Medical School, Piscataway, NJ 08854, USA

关键词: Collagen;    Inflammation;    Oxygen-derived free radical;    Ozone;   

DOI  :  10.1016/0014-5793(84)80931-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Collagen exposed to ozone or hydroxyl radicals was degraded in a time- and dose-dependent manner. This degradation was inhibited by free radical scavengers. Furthermore, lower levels of these oxidants did not degrade the molecule, but caused it to become susceptible to proteolytic degradation. We suggest an alternative mechanism by which oxygen-derived free radicals participate in the destruction of extracellular matrix observed during acute lung injury by oxidant gas, in addition to the commonly accepted proteinase-antiproteinase theory of lung injury.

【 授权许可】

Unknown