Dexamethasone inhibits ozone‐induced gene expression of macrophage inflammatory protein‐2 in rat lung

FEBS Letters

Adcock, I.¹  Das, A.¹  Haddad, E.-B.¹  Salmon, M.¹  Sun, J.¹  Liu, S.¹  Chung, K.F.¹  Barnes, P.J.¹ 

[1] Department of Thoracic Medicine, National Heart & Lung Institute, Dovehouse Street, London, SW3 6LY, UK

关键词: Ozone;    Rat lung;    Inflammation;    Northern blot;    MIP-2 mRNA;    Dexamethasone;   

DOI  :  10.1016/0014-5793(95)00333-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To address the potential role of the chemokine macrophage inflammatory protein-2 (MIP-2) in airway inflammation, we examined whether MIP-2 may play a role in ozone-induced neutrophilic inflammation of airways and its modulation by dexamethasone in rat lung. Following ozone exposure, MIP-2 mRNA expression in the lung peaked at 2 h after exposure and slowly declined thereafter. Dexamethasone suppressed ozone-induced MIP-2 mRNA expression and neutrophil accumulation in the lung. We suggest that the MIP-2 mRNA induction may switch on the neutrophilic influx observed in this model of lung inflammation. Furthermore, the MIP-2 expression is regulated by dexamethasone which may represent one of the mechanisms by which glucocorticoids exert their potent anti-inflammatory properties.

【 授权许可】

Unknown