Reduced maximum capacity of glycolysis in brown adipose tissue of genetically obese, diabetic (db/db) mice and its restoration following treatment with a thermogenic β‐adrenoceptor agonist

FEBS Letters

Cawthorne, M.A.¹  Young, P.¹  Levy, Alison L.¹  Wilson, Karen¹ 

[1] Beecham Pharmaceutical Research Division, Biosciences Research Centre, Yew Tree Bottom Road, Epsom, Surrey KT18 5XQ, England

关键词: Brown adipose tissue;    Blood glucose;    Glycolysis;    2-Deoxyglucose;    db/db mouse;   

DOI  :  10.1016/0014-5793(84)80903-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The maximal activities of the key glycolytic enzymes hexokinase and 6-phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates. Treatment of db/db mice with the thermogenic β-adrenoceptor agonist, BRL 26830, restored normoglycaemia. The only significant increase in activity of hexokinase and 6-phosphofructokinase in the BRL 26830-treated db/db mice occurred in brown adipose tissue where the total tissue activity increased 10- and 11-fold respectively. These changes together with increased 2-deoxyglucose uptake in vivo suggest that brown adipose tissue can play a quantitatively important role in the removal of glucose from the blood.

【 授权许可】

Unknown