The maximum capacity of glycolysis in brown adipose tissue and its relationship to control of the blood glucose concentration

FEBS Letters

Newsholme, Eric A.¹  Cooney, Gregory J.¹ 

[1] Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, England

关键词: Brown adipose tissue;    Hexokinase;    Phosphofructokinase;    Blood glucose;    Glycolysis;    Thermogenesis;   

DOI  :  10.1016/0014-5793(82)80807-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The maximum activity of the key glycolytic enzymes, hexokinase and 6-phosphofrustokinase, was measured in tissues of control and cold-acclimated rats. The only significant change in activity was seen in brown adipose tissue where the activity of these enzymes was increased 2-fold. This increase in glycolytic capacity along with the hypertrophy of BAT observed in cold acclimation suggests that this tissue could play an important role in glucose utilisation by the rat.

【 授权许可】

Unknown