Evidence for a role of phosphofructokinase and tRNA in the polyribosome disaggregation of amino acid deficiency

FEBS Letters

Rabinovitz, Marco¹ 

[1] Laboratory of Biological Chemistry, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, NIH, Bethesda MD, USA

关键词: Phosphofructokinase;    Tranfer ribonucleic acid;    Amino acid control;   

DOI  :  10.1016/0014-5793(91)80605-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The activity of rabbit muscle phosphofructokinase was inhibited by transfer ribonucleic acid. This inhibition was reduced by inclusion of an amino-acyl-tRNA charging system. The results are discussed in terms of the loss of ATP in amino acid deprived cells and in the critical role of fructose 1,6-diphosphate in peptide chain initiation.

【 授权许可】

Unknown