Excretion of ecdysteroids by schistosomes as a marker of parasite infection

FEBS Letters

De Reggi, M.L.¹  Torpier, G.²  Tsoupras, G.³  Capron, A.²  Fressancourt, P.²  Nirde, P.² 

[1] IMMUNOTECH S.A., Case 915, 13288 Marseille Cédex 9France;Centre d'Immunologie et de Biologie Parasitaire, INSERM (U167), CNRS (ERA 422), Institut Pasteur, BP 245, 59019 Lille Cédex, France;Laboratoire de Biologie Générale, CNRS (ERA 118), 12 rue de l'Université, 67000 Strasbourg, France

关键词: Schistosomiasis;    Body fluids;    Ecdysterone;    Mass spectrum analysis;    Radioimmunoassay;   

DOI  :  10.1016/0014-5793(84)80253-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Ecdysteroids produced by schistosomes are released in biological fluids of infected hosts. In the sera, the concentration of ecdysteroids correlates with the perimissiveness of the host to schistosome infection and its detection is available in the absence of positive parasitological tests. In the urine, ecdysteroid concentration decreases markedly after chemotherapy. 20-Hydroxyecdysone and its epimer were identified in the urine of infected patients using mass spectrometry. These data demonstrate for the first time that ecdysteroids are released by organisms. Moreover, they are potent molecules of parasite infection and can be used for parasite diagnosis.

【 授权许可】

Unknown