Hypoglycaemic effects of Ajuga extract in vitro and in vivo

Journal of Functional Foods

Ju-Yun Cheng¹  Teng-Hsu Wang²  Hsiu-Ju Wang³  Chang-Wei Hsieh³  Wai-Jane Ho⁴ 

[1] Corresponding author: Address: No. 168, University Rd., Dacun, Changhua 51591, Taiwan, ROC. Tel.: [phone]x6230;fax: [phone].;Department of Medicinal Botanicals and Health Applications, Da-Yeh University, Changhua 515, Taiwan, ROC;School of Pharmacy, National Defense Medical Center, Taipei 104, Taiwan, ROC;

关键词: Hypoglycaemic effect;    Ajuga species;    Ecdysterone;    Flavonoids;    Ultrasonic-assisted extraction;    Supercritical fluid extraction;   

DOI  :  

来源: DOAJ

【 摘 要 】

The Ajuga species with abundant flavonoids, terpenoids and other active compounds might be a potential remedies for diabetes. In this study, we used five common Ajuga species in Taiwan, including A. decumbens, A. nipponensis, A. pygmaea, A. taiwanensis and A. dictyocarpa, to determine the hypoglycaemic effects of the extracts in vitro and in vivo. Amongst the five Ajuga species, A. nipponensis contained the highest content of flavonoids (7.76 ± 0.21 mg/g) and ecdysterone (0.785 ± 0.031 mg/g). In addition, ultrasonic-assisted extraction (UAE) produced better yield than supercritical fluid extraction (SFE). Furthermore, A. nipponensis has the best effect in α-glucosidase inhibition (28.62 ± 1.56%) and glucose uptake (54.15 ± 2.56%). Subsequent STZ (streptozotocin)-induced diabetic mice administration of A. nipponesis extracts (200 mg/kg BW) moderately decreased postprandial blood glucose levels in. Thus, A. nipponensis extracts may be a potential remedy for diabetes in the future.

【 授权许可】

Unknown