Increase in cytosolic Ca2+ concentration during t‐butyl hydroperoxide metabolism by isolated hepatocytes involves NADPH oxidation and mobilization of intracellular Ca2+ stores

FEBS Letters

Bellomo, Giorgio¹  Thor, Hjördis¹  Orrenius, Sten¹ 

[1] Department of Forensic Medicine, Karolinska Institutet, PO Box 60400, S-10401 Stockholm, Sweden

关键词: Isolated hepatocyte;    Cytosolic Ca2+;    Phosphorylase a;    t-Butyl hydroperoxide;    NADPH;   

DOI  :  10.1016/0014-5793(84)80202-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Activation of phosphorylase a in hepatocytes incubated with t-butyl hydroperoxide indicates that hydroperoxide metabolism is associated with an increase in cytosolic free Ca²⁺ concentration which appears to be mediated by NADPH oxidation and to involve mobilization of intracellular Ca²⁺ stores.

【 授权许可】

Unknown