Reactions of Fe(II)‐ATP and Fe(II)‐citrate complexes with t‐butyl hydroperoxide and cumyl hydroperoxide

FEBS Letters

Rush, J.D.¹  Koppenol, W.H.¹ 

[1] Biodynamics Institute and Department of Chemistry and Biochemistry, Louisiana State University, Baton Rouge, LA 70803-1804 USA

关键词: Fenton reaction;    Adenosine triphosphate;    Citrate;    Cumyl hydroperoxide;    t-Butyl hydroperoxide;    Ferrous nucleotide;    Alkoxyl radical;   

DOI  :  10.1016/0014-5793(90)81452-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rate constants for the reactions of cumyl hydroperoxide and t-butyl hydroperoxide with ferrous complexes of ATP and citrate were measured at pH 7.4. These ligands are potential chelators of iron(II) in the low-molecular weight iron pool that may catalyze oxidative degradation of biomolecules. The second-order rate constants for the reduction of cumyl hydroperoxide and t-butyl hydroperoxide by ferrous ATP are 3.1 × 10³ and 1.3 × 10³ M⁻¹·s⁻¹, respectively, at 25°C and 0.11 M ionic strength. Rates of reduction by ferrous citrate are similar. Activation enthalpies for these reactions average 10 kcal/mol.

【 授权许可】

Unknown