Lack of prostaglandin involvement in the mitogenic effect of TSH on canine thyroid cells in primary culture

FEBS Letters

Boeynaems, J.M.¹  Roger, P.P.¹  Dumont, J.E.¹ 

[1] Institute of Interdisciplinary Research, School of Medicine, Université Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium

关键词: Thyroid;    Thyrotropin;    EGF;    Prostaglandin;    Indomethacin;    Proliferation;    Serum-free culture;   

DOI  :  10.1016/0014-5793(84)80059-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The production of prostaglandin E₂ (PGE₂) by cultured dog thyroid cells was high in a serum-containing medium and low in a serum-free, completely defined medium. Thyrotropin (TSH) and epidermal growth factor (EGF), two mitogenic factors for these cells, did not stimulate PGE₂ release. Indomethacin, at a concentration which completely inhibited PGE₂ production, had no effect on thyroid cell multiplication and DNA synthesis stimulated by TSH and EGF. It is concluded that cyclooxygenase products are not involved in the proliferation of canine thyroid cells and its control by TSH.

【 授权许可】

Unknown