Stimulation by thyrotropin and cyclic AMP of the proliferation of quiescent canine thyroid cells cultured in a defined medium containing insulin

FEBS Letters

Roger, Pierre P.¹  Servais, Patricia¹  Dumont, Jacques E.¹ 

[1] Institute of Interdisciplinary Research (IRIBHN), School of Medicine, Free University of Brussels, Campus Erasme, Route de Lennik 808, B-1070 Brussels and Biology Department, Euratom, Brussels, Belgium

关键词: Thyroid;    Thyrotropin;    Cyclic AMP;    Forskolin;    DNA synthesis;    Proliferation;    Serum-free culture;   

DOI  :  10.1016/0014-5793(83)80569-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have developed serum-free primary cultures of differentiated follicular dog thyroid cells which allow the study of the hormonal control of cell proliferation. The cooperation of insulin and increasing cellular cyclic AMP by thyrotropin triggers the DNA synthesis and the proliferation. Dog thyroid cells are an example of a system in which cyclic AMP is a sufficient signal to stimulate the proliferation in quiescent cells.

【 授权许可】

Unknown