An anti‐acetylcholine receptor monoclonal antibody cross‐reacts with phosvitin

FEBS Letters

Pizzighella, Sergio¹  Souroujon, Miry C.¹  Fuchs, Sara¹  Mochly-Rosen, Daria¹  Sharp, Ayala¹  Gordon, Adrienne S.¹ 

[1] Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel

关键词: Acetylcholine receptor;    Monoclonal antibody;    Phosvitin;    Antigenic determinant;   

DOI  :  10.1016/0014-5793(83)80456-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rabbit and mouse anti-Torpedo acetylcholine receptor antibodies cross-reacted partially with the highly phosphorylated protein, phosvitin. We have selected an anti-Torpedo acetylcholine receptor monoclonal antibody which binds specifically to phosvitin; this binding is inhibited by acetylcholine receptor. These findings suggest that a phosphorylated amino acid residue may be a part of the determinant on the acetylcholine receptor recognized by this monoclonal antibody.

【 授权许可】

Unknown