FEBS Letters | |
Proton currents and protein motion in membranes | |
Marvin, D.A.1  | |
[1] European Molecular Biology Laboratory, 6900 Heidelberg, FRG | |
关键词: α-Helix; Chemiosmosis; Protein conformation; Protein transport; Proton gradient; Proton pump; | |
DOI : 10.1016/0014-5793(83)80235-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A mechanism is proposed whereby a proton gradient along a membrane-spanning α-helix is coupled to small changes in the torsional angles around the α-helix peptide bonds. Small concerted changes in the torsional angles are coupled to a change in the unit twist of the α-helix; a change in the unit twist is coupled to a change in the crossing angle between neighbouring α-helices; and a change in the crossing angle is coupled to a change in the size and shape of an assembly of α-helices. Following this logical linkage in one direction shows how a proton gradient could induce a pumping motion in an assembly of α-helices; following it in the other direction shows how motion in an assembly of α-helices could pump protons.
【 授权许可】
Unknown
【 预 览 】
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RO201912020284274ZK.pdf | 421KB | download |