Neo‐kyotorphin (Thr—Ser—Lys—Tyr—Arg), a new analgesic peptide

FEBS Letters

Takagi, Hiroshi³  Akita, Tadashi²  Kitagawa, Kouki²  Amano, Hiroo³  Fukui, Kiyoshi¹  Kiso, Yoshiaki²  Nobuyuki, Kawai² 

[1] Department of Pharmacology, Kagawa Medical School, Miki-cho, Kida-gun, Kagawa-ken 761-07, Japan;Faculty of Pharmaceutical Sciences, University of Tokushima, Tokushima 770, Japan;Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto 606, Japan

关键词: Neo-kyotorphin;    Bovine brain;    Peptide synthesis;    Analgesia;    Kyotorphin;    Hemoglobin;    Z;    benzyloxycarbony;    (Z(OMe);    p-methoxybenzyloxycarbonyl;    TFA;    trifluoroacetic acid;    Tos;    p-toluenesulphonyl;   

DOI  :  10.1016/0014-5793(82)80621-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The amino acid sequence of a newly isolated pentapeptide, neo-kyotorphin from bovine brain was synthetically verified to be Thr-Ser-Lys-Tyr-Arg corresponding to the C-terminal portion of hemoglobin α-chain. The synthetic neo-kyotorphin showed the dose-dependent analgesia in mice which was approximately equal to that of Leu-enkephalin.

【 授权许可】

Unknown