Neo‐kyotorphin, an analgesic peptide isolated from human lung carcinoma

FEBS Letters

Tsou, K.¹  Guo, S.Y.¹  Zhu, Y.X.¹  Chen, Z.G.¹  Hsi, K.L.¹  Zhang, S.Y.¹  Fang, P.F.¹  Kao, Y.S.¹  Wu, S.X.¹  Zhang, H.L.¹ 

[1] Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 319 Yue Yang Road, Shanghai 200031, China

关键词: (Human lung) Carcinoma Neo-kyotorphin Analgesic peptide Analgesic activity Peptide isolation Peptide synthesis;   

DOI  :  10.1016/0014-5793(86)81027-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A pentapeptide with analgesic activity has been isolated from human lung squamous cell carcinoma and from three other types of propagated tumors of human lung small-cell carcinoma (SCC), adenoma (AD) and large-cell carcinoma (LCC) in nude mice. The amino acid sequence of the peptide has been revealed to be H-Thr-Ser-Lys-Tyr-Arg-OH, which is exactly the same as that of neo-kyotorphin, an analgesic peptide originally isolated from bovine brain [(1982) Life Sci. 31, 1733]. No neo-kyotorphin could be isolated from normal lung tissue using the same procedures as those used for carcinomas. The results suggest that the presence of neo-kyotorphin in the lung carcinoma may represent the ectopic expression of peptide hormone. Our findings constitute the first example of a human lung carcinoma producing analgesic peptide.

【 授权许可】

Unknown