The generation of hydroxyl radicals following superoxide production by neutrophil NADPH oxidase

FEBS Letters

Davoli, A.¹  Thornalley, P.J.¹  Bellavite, P.¹  Bannister, J.V.¹  Rossi, F.¹ 

[1] Inorganic Chemistry Laboratory, University of Oxford, Oxford OX1 3QR, England

关键词: Superoxide;    Hydroxyl radical;    Neutrophils;    NADPH oxidase;    Transferrin;    EPR;   

DOI  :  10.1016/0014-5793(82)80755-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Stimulated neutrophils generate superoxide and hydroxyl radicals. A membrane-bound NADPH oxidase, inactive in the resting state, is responsible for superoxide production. The production of hydroxyl radicals is through a secondary reaction. A Fenton-catalysed Haber—Weiss reaction is proposed. Transferrin was used as the catalyst in this investigation.

【 授权许可】

Unknown