Changes in phosphoproteins of chicken bone matrix in vitamin D‐deficient rickets

FEBS Letters

Lian, Jane B.²  Cohen-Solal, Lola²  Glimcher, Melvin J.¹  Kossiva, Dora¹ 

[1] The Laboratory for Skeletal Disorders and Rehabilitation, The Children's Hospital Medical Center, 300 Longwood Ave., Boston, MA 02115, USA;Departments of Orthopaedic Surgery and Biological Chemistry, Harvard Medical School, USA

关键词: Bone matrix;    O-phosphoserine;    Phosphoprotein;    Vitamin-D;    Rickets;   

DOI  :  10.1016/0014-5793(82)81085-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Vitamin D-deficiency and rickets was produced in growing chicks. The resulting decrese in mineralization of whole bone and of fractions separated by density centrifugation was accompanied by a very significant decrease in the contents of O-phosphoserine and O-phosphothreonine. Likewise, the total amount of O-phosphoserine and O-phosphothreonine and the concentrations of these phosphoamino acids in EDTA extracts and in fractions obtained by molecular sieving was also reduced. These data provide the first in vivo evidence that phosphoproteins may be critically involved in the calcification of bone.

【 授权许可】

Unknown