Vitamin K‐dependnet carboxylases from non‐hepatic tissues

FEBS Letters

Hendrix, H.¹  Vermeer, C.¹  Daemen, M.¹ 

[1] Department of Biochemistry, State University of Limburg, P.O. Box 616, 6200 MD Maastricht, The Netherlands

关键词: Carboxylase;    Vitamin K;    Warfarin;    Liver γ-carboxylumatic acid;    Anticoagulant therapy;   

DOI  :  10.1016/0014-5793(82)80832-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The presence of vitamin K-dependent carboxylase was investigated in the microsomal fraction of 20 different types of bovine tissue. Except for muscle, veins, lymphocytes and bone membrane, carboxylase was found in all these preparations, albeit in varying amounts. No differences could be detected between these carboxylating systems with respect to their affinity for vitamin K and warfarin. Most of the endogenous substrates had some affinity towards antiprothrombin or antifactor X.

【 授权许可】

Unknown