Characteristics of vitamin K‐dependent carboxylating systems from human liver and placenta

FEBS Letters

Vermeer, Cees¹  de Metz, Menno¹  Soute, Berry A.M.¹ 

[1] Department of Biochemistry, State University of Limburg, P.O. Box 616, 6200 MD Maastricht, The Netherlands

关键词: Carboxylase;    Vitamin K;    Warfarin;    Liver;    Placenta γ-Carboxyglutamic acid;   

DOI  :  10.1016/0014-5793(82)80954-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Bovine liver vitamin K-dependent carboxylase was compared with that obtained from human liver and placenta. Human liver microsomal preparations contained more endogenous substrate than did bovine preparations, but no differences were found between the two types of hepatic enzyme. This observation demonstrates that the bovine liver carboxylating enzyme system is a good model system which will help us to understand vitamin K action in man. Placental carboxylase differed from the liver systems because only vitamin K hydroquinone and not vitamin K quinone could be used as a coenzyme for the carboxylation reaction. Obviously, vitamin K reductase was absent in these preparations.

【 授权许可】

Unknown