A higher aneurysmal subarachnoid hemorrhage incidence in women prior to menopause: a retrospective analysis of 4,895 cases from eight hospitals in China

Quantitative Imaging in Medicine and Surgery

Lin Zhao⁵  Jian He²  Heng Liu⁷  Jian Yang⁴  Lihong Zhang⁸  Zheng Han Yang⁹  Lin Yang³  Guang Ming Peng⁶  Anil Ahuja^5,10  Xian Jun Zeng¹  Yao Li^5,10  Yì Xiáng J. Wáng^5,10 

[1] Department of Radiology, North Sichuan Medical College Hospital, Nanchong 637000, China;Department of Radiology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China;Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China;Department of Radiology, The First Affiliated Hospital of Xi’an Jiao Tong University, Xi’an 710061, China;Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China;Department of Radiology, The General Hospital of Guangzhou Military Command, Guangzhou 510010, China;Department of Radiology, The Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China;;Department of Neurology,;Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Prince of Wales Hospital, New Territories, Hong Kong SAR, China;

关键词: Physiological gender difference;    epidemiology;    aneurysmal subarachnoid hemorrhage;    cerebral aneurysm;   

DOI  :  10.21037/qims.2016.01.06

学科分类：外科医学

来源: AME Publications

【 摘 要 】

Background: Subarachnoid hemorrhage (SAH) from a ruptured cerebral aneurysm is a devastating disease. Despite the risk factors, including hypertension, cigarette smoking and alcohol use, are more common in men, aneurysmal SAH belongs to a few diseases which the incidence is higher in women than in men. Sex hormones, especially estrogen, might be protective against this condition. Hormone replacement therapy (HRT) seems to be associated with a reduced risk for aneurysmal SAH. This study aims to know the prevalence of aneurysmal SAH of men and women at different ages.

Methods: The age and gender information of 4,895 case of aneurysmal SAH (3,016 females, 1,879 males) were collected retrospectively from eight institutions in mainland China. The prevalence of aneurysmal SAH of men and women at different ages was analyzed.

Results: The data showed women had a higher incidence of aneurysmal SAH than men starting at late thirties, and men might have a higher incidence of aneurysmal SAH than women only before 37-year-old.

Conclusions: Menopause may not be the only dominant factor causing higher incidence of aneurysmal SAH in women than in men.

【 授权许可】

Unknown