Post-diagnosis quality of life and mortality in non-Hispanic White and Hispanic women diagnosed with invasive breast cancer.

epidemiology;HRQOL;quality of life;breast cancer;mortality;Hispanic

Delvon T. Mattingly

University:University of Louisville

Department:Epidemiology and Population Health

关键词: epidemiology;    HRQOL;    quality of life;    breast cancer;    mortality;    Hispanic;   

Others  :  https://ir.library.louisville.edu/cgi/viewcontent.cgi?article=4221&context=etd

美国|英语

来源: The Universite of Louisville's Institutional Repository

【 摘 要 】

The prevalence of breast cancer is increasing, and the health-related quality of life (HRQOL) of breast cancer survivors may help to further understand survivorship. This study evaluated HRQOL as a potential prognostic factor for mortality among Non-Hispanic White (NHW) and Hispanic women diagnosed with invasive breast cancer. Data were used from the Health, Eating, Activity, and Lifestyle (HEAL) Study. Data for 351 participants were analyzed for associations between HRQOL scores (subscale, component) and mortality. Cox proportional hazards regression was conducted to assess the relationship between HRQOL and mortality outcomes (all-cause, breast cancer-specific, non-cancer). Median follow-up time from HRQOL assessment (approximately 36-months post-diagnosis) to the end of the study period was 11.2 years. There was a statistically significant association between the physical component summary score and all mortality outcome measures for all women and when stratified by race/ethnicity. HRQOL evaluated post-diagnosis was a significant predictor of long-term mortality in this population.