Investigation of Tacrolimus Loaded Nanostructured Lipid Carriers for Topical Drug Delivery

Bulletin of the Korean chemical society

Xu Ying Ji¹  So Hee Nam¹  Jong Sang Park¹ 

关键词: Tacrolimus;    Nanostructured lipid carriers;    Topical drug delivery;    Nanoparticles;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

The objective of this investigation was to develop nanostructured lipid carriers (NLCs) of tacrolimus by the hot homogenization technique by sonication. NLCs are commonly prepared by emulsification and lyophilization. The feasibility of fabricating tacrolimus-loaded NLCs was successfully demonstrated in this study. The developed NLCs were characterized in terms of their particle size, zeta potential, entrapment efficiency (EE) of tacrolimus, and morphology. Studies were conducted to evaluate the effectiveness of the NLCs in improving the penetration rate through hairless mouse skin. Tacrolimus-loaded NLCs were found to have an average size of 123.4 ± 0.3 nm, a zeta potential of −24.3 ± 6.2 mV, and an EE of 50%. In vitro penetration tests revealed that the tacrolimus-loaded NLCs have a penetration rate that is 1.64 times that of the commercial tacrolimus ointment, Protopic®.

【 授权许可】

Unknown