Development and Characterization of Voriconazole loaded Solid Lipid Nanoparticle for Topical Drug Delivery.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Suman Narapureddy¹  T Veera Reddy²  Varanasi S N Murthy³  Naresh Modepalli.⁴ 

[1] Corporate Quality Assurance, Cipla Ltd.;Vikramasimhapuri University;Dr. Reddy’s Laboratories;InvaGen Pharmaceuticals, Central Islip

关键词: Voriconazole;    Solid lipid nanoparticles;    Topical drug delivery;    Zeta potential;   

DOI  :  10.33887/rjpbcs/2021.12.2.23

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

Voriconazole is one of the second generation antibiotics which are synthetic triazole with improvedanti-fungal activity. Currently voriconazole is available commercially as intravenous and oral formulations. Themarketed formulations are associated with the hepatic and visual abnormalities. Voriconazole is also playing amajor role in the treatment of topical disease like aspergillosis, candidasis etc. The present study is to assessthe role of solid lipid nanoparticles in improving the therapeutic efficacy of voriconazole. In the presentresearch solid lipid nanoparticles were prepared by the high shear homogenization method using compritolATO 888, stearic acid and tristearine as lipids, Polaxomer 188 as surfactant and soya lecithin as co-surfactant.The prepared solid lipid nanoparticles were evaluated for their physicochemical properties like particle size,PDI, Entrapment efficiency, drug release study etc. Among all the 9 formulations the solid lipid nanoparticlesprepared with stearic acid were found to have the good physicochemical properties. Solid lipid nano particlesprepared with 300 mg of stearic acid found to have the lesser particle size (244.58±07.45) and good release incomparison with other formulations. The polydispersity index values were also found to have less than 0.5 forall the formulations which is an indication for uniform particle size. Voriconazole solid lipid nanoparticlesprepared with 300 mg of stearic acid was found to have the controlled drug release. Solid lipid nanoparticlesprepared with 300 mg of stearic acid was found to have the good physical stability up to 3 months.

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