Formulation, Development and Evaluation of Controlled Release Film Forming Gel for Antiseptic Activity.

Research Journal of Pharmaceutical, Biological and Chemical Sciences

article

Tulsidas Nimbekar¹  Shishupal Bodhankar.¹ 

[1] Bajiraoji Karanjekar College of Pharmacy

关键词: Film forming polymers;    Topical drug delivery;    Antiseptic activity;    povidone-iodine.;   

DOI  :  10.33887/rjpbcs/2020.11.3.21

学科分类：工程和技术（综合）

来源: Research Journal of Pharmaceutical, Biological and Chemical Sciences

【 摘 要 】

The suitability of drug with respect to lower dose, solubility, lower molecular weight and short half- life makes this drug as a suitable candidate for administration by transdermal route. The effectiveness oftopical therapy depends on the physicochemical properties of the drug and adherence of the patient to thetreatment regimen as well as the system’s ability to adhere to skin during the therapy so as to promote drugpenetration through the skin barrier. Conventional formulations for topical and dermatological administrationof drugs have certain limitations like poor adherence to skin, poor permeability and compromised patientcompliance. In the present study povidone-iodine transdermal films were prepared by various methods usingpolymer Eudragit L-100. The prepared transdermal films were evaluated for Appearance, thickness, foldingendurance, weight variation, flatness, moisture absorption, moisture loss, moisture content, Foldingendurance, water vapor transmission, and in vitro drug diffusion study. Drug polymer interactions weredetermined by FTIR. The transdermal films prepared by using Eudragit L 100 showed good physical properties.The formulation batch (F5) containing Eudragit L 100 showed maximum Antiseptic activitybyfilm which wasprepared by spray method & solvent casting method.

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