Cytotoxic Polyketides from the Marine Sponge Discodermia calyx

Bulletin of the Korean chemical society

Tayyab A. Mansoor¹  Xuan Luo¹  Jongki Hong¹  Pramod B. Shinde¹  Jee H. Jung¹  Chong-O. Lee¹ 

关键词: Marine sponge;    Discodermia calyx;    Polyketide;    Cytotoxicity;    Marfey analysis;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

Bioassay-guided fractionation of the MeOH extract from the sponge Discodermia calyx collected off the coast of Jeju Island, South Korea, led to the isolation of a polyketide, icadamide C (1), along with previously reported theopederin K (3). Structure elucidation was performed by a combination of high resolution mass and 2D-NMR (principally COSY, HMBC, HSQC, and NOESY) spectroscopy. Stereochemistry of compound 1 was determined as 2R*, 3R*, 6R*, 10S*, 11S*, 12R*, 13S*, 15R* and 2`S by NMR data and Marfey analysis. Isolated metabolites displayed potent cytotoxic activity against a small panel of five human solid tumor cell lines with ED₅₀ values of less than 0.1 レg/mL.

【 授权许可】

Unknown