Obionin B: an o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the order Pleosporales

TETRAHEDRON LETTERS

卷:52

Article

Ayers, Sloan¹  Graf, Tyler N.¹  Adcock, Audrey F.²  Kroll, David J.²  Shen, Qi³  Swanson, Steven M.³  Wani, Mansukh C.⁴  Darveaux, Blaise A.⁵  Pearce, Cedric J.⁵  Oberlies, Nicholas H.¹ 

[1] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27402 USA

[2] N Carolina Cent Univ, Dept Pharmaceut Sci, BRITE, Durham, NC 27707 USA

[3] Univ Illinois, Dept Med Chem & Pharmacognosy, Chicago, IL 60612 USA

[4] Res Triangle Inst, Nat Prod Lab, Res Triangle Pk, NC 27709 USA

[5] Mycosynthetix Inc, Hillsborough, NC 27278 USA

关键词: Polyketide;    Cytotoxicity;    Pleosporales;    o-Naphthoquinone;   

DOI  :  10.1016/j.tetlet.2011.07.102

来源: Elsevier

【 摘 要 】

A fungal extract (MSX 63619), from the Mycosynthetix library of over 50,000 fungi, displayed promising cytotoxicity against a human tumor cell panel. Bioactivity-directed fractionation led to the isolation of an o-pyranonaphthoquinone decaketide, which we termed obionin B (1). The structure of 1 was deduced via spectroscopic and spectrometric techniques. The IC50 value of 1 was moderate, ranging from 3 to 13 mu M, depending on the cell line tested. (C) 2011 Elsevier Ltd. All rights reserved.

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