Synthesis of New Anthracycline Derivatives Containing Lactic or Stearic Acid Moiety

Bulletin of the Korean chemical society

Dong Jin Yoo¹  Young S. Rho¹  Wan-Joong Kim¹ 

关键词: Daunomycin;    Doxorubicin;    Anthracycline derivatives;    Lactic acid;    Stearic acid;   

DOI  :  

学科分类：化学（综合）

来源: Korean Chemical Society

【 摘 要 】

logues 2-9 as potential anticancer agents were synthesized from daunomycin (1a) and doxorubicin (1b). Compounds 2, 6, and 7 were prepared by the nucleophilic displacement type esterification of a 14-bromodaunomycin (1c) with a sodium lactate, and stearic acid, respectively. Compounds 3-5 and 7-9 were prepared by the reaction of either daunomycin (1a) or doxorubicin (1b) with L-lactic and stearic acids in the presence of EDCI/PP reagents.

【 授权许可】

Unknown