Accelerating the Development of Novel Molecular Imaging Probes: A Role for High-Throughput Screening

Journal of Nuclear Medicine

Nathan J. Mutic¹  Adam Lander¹  H. Charles Manning¹  Eliot McKinley¹ 

[1] Vanderbilt University Medical Center Nashville, Tennessee Vanderbilt University Medical Center Nashville, Tennessee Vanderbilt University Medical Center Nashville, Tennessee

关键词: molecular imaging;    imaging probe discovery;    HTS;   

DOI  :  10.2967/jnumed.108.053009

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

Molecular imaging is a rapidly emerging research tool and clinical discipline aimed at noninvasive, quantitative visualization of in vivo molecular processes occurring at cellular and subcellular levels. At present, advancement of the molecular imaging field is driven by the development of improved imaging hardware for use in preclinical and clinical settings, the identification and validation of new, biologically relevant imaging targets, and the development of improved imaging probes derived from novel chemistries. Of these 3 essential facets, which comprise a majority of current molecular imaging research, hardware development and novel target discovery significantly outpace the development and clinical advancement of new molecular imaging probes, particularly with respect to cancer imaging.

【 授权许可】

Unknown