Biomarkers for Drug Discovery: Important Aspects of in vitro Assay Design for HTS and HCS Bioassays

Croatica Chemica Acta

Irwin, William A.¹  Jelić, Dubravko¹  Antolović, Roberto¹ 

[1] GlaxoSmithKline Istraživački Centar, Zagreb, Hrvatska

关键词: HTS;    HCS;    assay;    in vitro;    models;    optimization;    biomarkers;   

DOI  :  

学科分类：化学（综合）

来源: Croatica Chemica Acta

【 摘 要 】

High throughput screening (HTS) is the foundation of current drug discovery to assay drug candidates for toxicity and biological effects (i.e. off-target and on-target responses, respectively). HTS is typically based on measuring...

【 授权许可】

Unknown