MTA1 Is Up-regulated in Colorectal Cancer and Is Inversely Correlated with Lymphatic Metastasis

Cancer Genomics - Proteomics

RACHEL HARGEST²  WEN G. JIANG³  JUN LI¹  LIN YE²  PING-HUI SUN²  ZHONGTAO ZHANG⁴  LUCY SATHERLEY² 

[1] ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaepartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. China;ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.;ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff University–Capital Medical University Joint Centre for Biomedical Research & Cancer Institute, Capital Medical University, Beijing, P.R. Chinaardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.ardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff University–Capital Medical University Joint Centre for Biomedical Research & Cancer Institute, Capital Medical University, Beijing, P.R. Chinaepartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff University–Capital Medical University Joint Centre for Biomedical Research & Cancer Institute, Capital Medical University, Beijing, P.R. Chinaardiff University–Capital Medical University Joint Centre for Biomedical Research & Cancer Institute, Capital Medical University, Beijing, P.R. Chinaardiff China Medical Research Collaborative, Cardiff University School of Medicine, Cardiff, U.K.epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaardiff University–Capital Medical University Joint Centre for Biomedical Research & Cancer Institute, Capital Medical University, Beijing, P.R. China;epartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaepartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. Chinaepartment of General Surgery, Beijing Key Laboratory of Cancer Invasion and Metastasis Research & National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Xi-Cheng District, Beijing, P.R. China

关键词: MTA1;    VEGFC;    lymphatic metastasis;    colorectal carcinoma;   

DOI  :  

来源: Delinasios GJ CO

【 摘 要 】

Background: Metastasis-associated protein 1 (MTA1) plays an important role in tumourigenesis and progression of certain cancer types. In the current study, we analyzed the relationship between MTA1 expression and disease progression of colorectal cancer (CRC). Materials and Methods: CRC tissues (n=93) and adjacent normal colorectal tissues (n=70) were analyzed by quantitative real-time polymerase chain reaction. MTA1 knockdown was established in RKO and HT115 cells using MTA1 siRNA. Results: The expression of MTA1 was significantly increased in CRC tissues compared to paired normal colorectal tissues, but decreased expression of MTA1 was correlated with poor prognosis (higher lymph node involvement stage, TNM stage, local invasion and recurrence) that was associated with increased expression of VEGFC and -D and the receptor VEGFR3. Conclusion: MTA1 is up-regulated in CRC. MTA1 expression is inversely associated with lymphatic metastases and the expression of VEGFC, VEGFD and VEGFR3.

【 授权许可】

Unknown